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How a metabolite protects the enzyme that consumes it

6 days 23 hours ago
Metabolites are consumed by enzymes to produce other vital molecules as well as to control metabolite levels. But how do cells avoid consuming too much? Researchers from the MPI of Biochemistry, with the University of Nevada, Las Vegas, and the de Duve Institute in Brussels, have deciphered such molecular regulation in tryptophan metabolism. The essential amino acid tryptophan binds to a second site on the enzyme TDO2, distinct from where it is consumed. This sequesters a region needed by two effectors, the kinase CK2 and the ubiquitin ligase CUL1–β-TrCP, which act sequentially to signal TDO2 degradation. The findings are now published in Molecular Cell.

Zoetis Takes Over #296 Spot From ResMed

6 days 23 hours ago
In the latest look at the underlying components of the S&P 500 ordered by largest market capitalization, Zoetis Inc (Symbol: ZTS) has taken over the #296 spot from ResMed Inc. (Symbol: RMD), according to The Online Investor. Market capitalization is an important data poi

Zoetis Takes Over #296 Spot From ResMed

6 days 23 hours ago
In the latest look at the underlying components of the S&P 500 ordered by largest market capitalization, Zoetis Inc (Symbol: ZTS) has taken over the #296 spot from ResMed Inc. (Symbol: RMD), according to The Online Investor. Market capitalization is an important data poi

Zoetis Takes Over #296 Spot From ResMed

6 days 23 hours ago
In the latest look at the underlying components of the S&P 500 ordered by largest market capitalization, Zoetis Inc (Symbol: ZTS) has taken over the #296 spot from ResMed Inc. (Symbol: RMD), according to The Online Investor. Market capitalization is an important data poi